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KMID : 0043320040270121238
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Archives of Pharmacal Research
2004 Volume.27 No. 12 p.1238 ~ p.1244
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Suppressive Effects of Platycodon grandiflorum on the Progress of Carbon Tetrachloride-Induced Hepatic Fibrosis
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Lee Kyung-Jin
Kim Ji-Young
Jung Kyung-Sik
Choi Chul-Yung
Chung Young-Chul
Kim Dong-Hee
Jeong Hye-Gwang
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Abstract
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The suppressive effects of Platycodi Radix (Changkil: CK), the root of Platycodon grandiflorum A. DC (Campanulaceae), on the progress of acute carbon tetrachloride -induced hepatic fibrosis were investigated in the rat. CK significantly suppressed -induced hepatic necrosis and inflammation, as determined by the serum enzymatic activities of alanine and aspartate aminotransferase and serum tumor necrosis factor- levels, in dose-dependent manners. In addition, the increased hepatic fibrosis after acute treatment was suppressed by the administration of CK. CK also significantly prevented the elevation of hepatic 1(I) procollagen (type I collagen) mRNA and -smooth muscle actin ( -SMA) expressions in the liver of -intoxicated rats and also suppressed the induction of -SMA and type I collagen in cultured hepatic stellate cells, in dose-dependent manners. These results suggest that the suppressive effects of CK against the progress of acute -induced hepatic fibrosis possibly involve mechanisms related to its ability to block both hepatic inflammation and the activation of hepatic stellate cells.
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KEYWORD
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Platycodi Radix, Carbon tetrachloride, Hepatic fibrosis, Hepatic stellate cells
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